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KMID : 1161420210240111206
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Journal of Medicinal Food
2021 Volume.24 No. 11 p.1206 ~ p.1212
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An Investigation Into the Degree of Sinus Mucosal Delivery of Inhaled Black Cumin Volatile and Peppermint Essential Oils
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Ture Nurullah
Yildirim Cafer
Pinarbasli Ozgur
Ozudogru Erkan
Cingi Cemal
Demirci Fatih
Karaca Nursenem
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Abstract
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The aim of this study was to investigate the quantity of volatile components reaching the sinus mucosa (SM) by inhalation, which is responsible for the therapeutic effect, as a first step toward targeted drug design. In this study, 18 Wistar-Albino female rats with an average weight between 200 and 250?g were used. The rats to be used in the study were randomized: Black cumin (BC) essential oil group (group 1) (n?=?6), Peppermint essential oil (PEO) group (group 2) (n?=?6), and Control (group 3) (n?=?6). Volatile oils were inhaled in group 1 and 2; in the control group volatile oils were not inhaled. In all groups, SM was removed and essential volatile oil composition was determined. In group 1, α-pinene was identified as the principal component in the gas phase from five different glass bottles containing SM. The data obtained were evaluated using the single sample T-test and results show that the α-pinene component in the group of inhaled BC essential oil reached significance (P?
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KEYWORD
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black cumin, essential oils, inhalation, peppermint, sinus mucosa
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